SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity

Front Immunol. 2024 Feb 13:15:1362224. doi: 10.3389/fimmu.2024.1362224. eCollection 2024.

Abstract

Suppressor of cytokine signaling 1 (SOCS1) is a potent regulator immune cell responses and a proven tumor suppressor. Inhibition of SOCS1 in T cells can boost antitumor immunity, whereas its loss in tumor cells increases tumor aggressivity. Investigations into the tumor suppression mechanisms so far focused on tumor cell-intrinsic functions of SOCS1. However, it is possible that SOCS1 expression in tumor cells also regulate antitumor immune responses in a cell-extrinsic manner via direct and indirect mechanisms. Here, we discuss the evidence supporting the latter, and its implications for antitumor immunity.

Keywords: SOCS1; antigen presentation; checkpoint inhibition; growth control; tumor immunogenicity; tumor suppressor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Neoplasms*
  • Suppressor of Cytokine Signaling 1 Protein / genetics
  • Suppressor of Cytokine Signaling 1 Protein / metabolism
  • Suppressor of Cytokine Signaling Proteins* / metabolism
  • T-Lymphocytes / metabolism

Substances

  • Suppressor of Cytokine Signaling 1 Protein
  • Suppressor of Cytokine Signaling Proteins
  • SOCS1 protein, human

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by a Project grant from the Canadian Institutes of Health Research (CIHR) to SI (PJT-153174).