Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA

Fernando H Centeno; Ahmed M Hamdi; Todd M Lasco; Mayar Al Mohajer

doi:10.1017/ash.2024.16

Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA

Antimicrob Steward Healthc Epidemiol. 2024 Feb 12;4(1):e20. doi: 10.1017/ash.2024.16. eCollection 2024.

Authors

Fernando H Centeno¹, Ahmed M Hamdi^{1

2}, Todd M Lasco^{3

2}, Mayar Al Mohajer^{1

2}

Affiliations

¹ Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
² Baylor St. Luke's Medical Center, Houston, TX, USA.
³ Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Abstract

We report 9 patients with invasive Bartonella infections, including 5 with endocarditis, who were diagnosed with microbial cell-free DNA next-generation sequencing and Bartonella serology studies. Diagnosis with plasma mcfDNA NGS enabled a faster clinical and laboratory diagnosis in 8 patients. Prompt diagnosis impacted antibiotic management in all 9 patients.