Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Naomi Shek; Anna-Maria Choy; Chim C Lang; Bruce E Miller; Ruth Tal-Singer; Charlotte E Bolton; Neil C Thomson; James D Chalmers; Matt J Bown; David E Newby; Faisel Khan; Jeffrey T J Huang

doi:10.1038/s41514-024-00143-7

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

NPJ Aging. 2024 Feb 27;10(1):15. doi: 10.1038/s41514-024-00143-7.

Authors

Affiliations

¹ Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.
² Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
³ COPD Foundation, Miami, USA.
⁴ Global Allergy and Airways Patient Platform, Vienna, Austria.
⁵ Centre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
⁶ School of Infection and immunity, University of Glasgow, Glasgow, Scotland, UK.
⁷ Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
⁸ MRC / University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, Scotland, UK.
⁹ Systems Medicine, School of Medicine, University of Dundee, Dundee, UK. jtjhuang@dundee.ac.uk.

Abstract

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

Abstract

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