Multidrug resistance Gene-1 polymorphisms (C3435T and G2677T) and the risk of inflammatory bowel disease in Egyptian patients

Raghda Marzaban; Rania Mohamed Samy; Mona Ahmed Kassem; Mira Atef

doi:10.1016/j.ajg.2023.12.008

Multidrug resistance Gene-1 polymorphisms (C3435T and G2677T) and the risk of inflammatory bowel disease in Egyptian patients

Arab J Gastroenterol. 2024 Feb 26:S1687-1979(23)00118-1. doi: 10.1016/j.ajg.2023.12.008. Online ahead of print.

Authors

Raghda Marzaban¹, Rania Mohamed Samy², Mona Ahmed Kassem³, Mira Atef⁴

Affiliations

¹ Endemic Medicine Department-Faculty of Medicine-Cairo University, Egypt.
² Clinical pathology department-Faculty of Medicine-Cairo University, Egypt.
³ Department of Hepatology-Students᾿ hospital-Ministry of Health, Giza, Egypt.
⁴ Endemic Medicine Department-Faculty of Medicine-Cairo University, Egypt. Electronic address: mira.atef@kasralainy.edu.eg.

PMID: 38413324
DOI: 10.1016/j.ajg.2023.12.008

Abstract

Background and study aims: The multidrug resistance 1 (MDR1) gene is a gene involved in the pathogenesis of inflammatory bowel disease (IBD).The aim of the study is to investigate the association of MDR-1 gene polymorphisms (C2345T and G2677T) and IBD incidence in Egyptian patients, and its relation with disease severity.

Patients and methods: This is a case-control study where genotyping of MDR-1 gene C3435T and G2677T single nucleotide polymorphisms (SNPs) were assayed.

Results: Forty naïve IBD patients, who were composed of 25 UC and 15CD, were compared to 60 healthy controls. They were young aged with significant female predominance, particularly in CD (P = 0.004). UC was mainly (48 %) presented in moderate severity while CD was mainly (53.3 %) presented with mild severity. MDR-1 gene C3435T SNP was not statistically related to IBD, whether in terms of genotypes or alleles, yet its T allele was significantly related to moderate cases of UC (P = 0.014). However, GG genotype of G2677T SNP was significantly low in IBD (P = 0.013), while TT genotype and T allele were significantly related to CD (P = 0.011, and 0.012 respectively). Moreover, G allele proved to be associated significantly with moderate cases of UC (P = 0.001) and mild cases of CD (P = 0.002).

Conclusions: MDR-I gene G2677T SNP GG genotype proved to be protective against IBD, thus may be considered in diagnostic workup of IBD including its severity.

Keywords: Crohn’s disease (CD); Inflammatory bowel disease (IBD); Multidrug resistance 1 (MDR1); Single nucleotide polymorphism (SNP); Ulcerative colitis (UC).