This paper briefly introduces the characteristics, research significance, and global reporting status of effect modification in network Meta-analysis, demonstrates the heterogeneity caused by effect modification in network Meta-analysis, and emphasizes the importance of exploring effect modification in network Meta-analysis. This paper also summarizes the normalized description and analysis strategies of effect modification in network Meta-analysis. Finally, by the case of "comparison of efficacy of three new hypoglycemic drugs in reducing body weight in type 2 diabetes patients", this paper demonstrates the realization of subgroup analysis and network Meta-regression in exploring effect modification, summarizes the advantages and disadvantages of the two methods, to provide references for future researchers.
本文简要介绍网状Meta分析中效应修饰作用的特点、研究意义和现状，并通过图表展示了效应修饰作用在网状Meta分析中导致的异质性问题，强调在网状Meta分析中探索效应修饰作用的重要性，总结5个不同场景下效应修饰作用的规范化描述和分析策略。通过“3类新型降糖药降低2型糖尿病患者体重的疗效比较”这一实际案例展示了亚组分析和网状Meta回归在网状Meta分析中对效应修饰作用的探索，并对二者的优缺点及注意事项进行总结，旨在为未来研究者提供参考。.