Genomes of Bacteroides ovatus, B. cellulosilyticus, B. uniformis, Phocaeicola vulgatus, and P. dorei isolated from gut cavernous fistulous tract micropathologies in Crohn's disease

Vaidhvi Singh; Gail West; Claudio Fiocchi; Fabio Cominelli; Caryn E Good; Michael R Jacobs; Alexander Rodriguez-Palacios

doi:10.1128/mra.01152-23

Genomes of Bacteroides ovatus, B. cellulosilyticus, B. uniformis, Phocaeicola vulgatus, and P. dorei isolated from gut cavernous fistulous tract micropathologies in Crohn's disease

Microbiol Resour Announc. 2024 Apr 11;13(4):e0115223. doi: 10.1128/mra.01152-23. Epub 2024 Feb 27.

Authors

Vaidhvi Singh^{1

2}, Gail West³, Claudio Fiocchi³, Fabio Cominelli^{1

2

4}, Caryn E Good^{5

6}, Michael R Jacobs^{5

6}, Alexander Rodriguez-Palacios^{1

2

6

7}

Affiliations

¹ Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
² Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
³ Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
⁴ University Hospitals Research and Education Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
⁵ Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
⁶ Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
⁷ Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Abstract

Surgically removed bowels from Crohn's disease patients exhibit a novel form of micropathologies known as cavernous fistulous tract microlesions (CavFT), resembling fissures. We announce the genomes/plasmids and antimicrobial resistance genes of six CavFT bacterial isolates representing the Bacteroidota genera Bacteroides and Phocaeicola. Plasmids were identified in Bacteroides cellulosilyticus and Phocaeicola vulgatus.

Keywords: Bacteroides; Bacteroidota; Phocaeicola; plasmid.

Abstract

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