SLAM medical imaging enabled by pre-chirp and gain jointly managed Yb-fiber laser

Yuting Xing; Runzhi Chen; Lihao Zhang; Yaobing Chen; Shu Zhang; Xincai Diao; Yang Liu; Yishi Shi; Zhiyi Wei; Guoqing Chang

doi:10.1364/BOE.506915

SLAM medical imaging enabled by pre-chirp and gain jointly managed Yb-fiber laser

Biomed Opt Express. 2024 Jan 22;15(2):911-923. doi: 10.1364/BOE.506915. eCollection 2024 Feb 1.

Authors

Yuting Xing^{1

2}, Runzhi Chen^{1

2}, Lihao Zhang^{1

2}, Yaobing Chen^{3

4}, Shu Zhang⁵, Xincai Diao^{1

2}, Yang Liu^{1

2}, Yishi Shi^{2

6}, Zhiyi Wei^{1

2

7}, Guoqing Chang^{1

2

7

8}

Affiliations

¹ Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.
³ Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
⁴ 72013TJ0513@hust.edu.cn.
⁵ The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
⁶ The Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China.
⁷ Songshan Lake Materials Laboratory, Dongguan, Guangdong 523808, China.
⁸ guoqing.chang@iphy.ac.cn.

Abstract

We demonstrate a pre-chirp and gain jointly managed Yb-fiber laser that drives simultaneous label-free autofluorescence-multiharmonic (SLAM) medical imaging. We show that a gain managed Yb-fiber amplifier produces high-quality compressed pulses when the seeding pulses exhibit proper negative pre-chirp. The resulting laser source can generate 43-MHz, 34-fs pulses centered at 1110 nm with more than 90-nJ energy. We apply this ultrafast source to SLAM imaging of cellular and extracellular components in various human tissues of intestinal adenocarcinoma, lung adenocarcinoma, and liver.