Overexpression of MTMR14 induced learning and memory impairments in 2-month-old C57 mice

Abstract

Multiple biological functions of MTMR14 including regulation of autophagy, inflammation and Ca²⁺ homeostasis have been reported. However, its functional contribution to learning and memory remains unclear. In this study, we investigated whether upregulation of MTMR14 induced cognitive impairment and the underlying mechanisms. MTMR14 level was significantly increased in cells or brain tissues that overexpressed P301S-tau. The fusion of autophagosome and lysosome was significantly inhibited by overexpression of MTMR14 or P301S-tau. Upregulation of MTMR14 led to cognitive impairments in 2-month-old mice by inhibiting synaptic protein expression. These findings suggest that MTMR14 may be a key risk factor for cognitive ability.

Keywords: Alzheimer’s diseases; Autophagy; Learning and memory; MTMR14; P301S; Synapse.