Novel Magnetic Resonance Imaging Tools for Hypertrophic Cardiomyopathy Risk Stratification

Life (Basel). 2024 Jan 30;14(2):200. doi: 10.3390/life14020200.

Abstract

Hypertrophic cardiomyopathy (HCM) is a common genetic disorder with a well described risk of sudden cardiac death; however, risk stratification has remained a challenge. Recently, novel parameters in cardiac magnetic resonance imaging (CMR) have shown promise in helping to improve upon current risk stratification paradigms. In this manuscript, we have reviewed novel CMR risk markers and their utility in HCM. The results of the review showed that T1, extracellular volume, CMR feature tracking, and other miscellaneous novel CMR variables have the potential to improve sudden death risk stratification and may have additional roles in diagnosis and prognosis. The strengths and weaknesses of these imaging techniques, and their potential utility and implementation in HCM risk stratification are discussed.

Keywords: T1; T2; cardiac magnetic resonance imaging; feature tracking; hypertrophic cardiomyopathy; prognosis.

Publication types

  • Review

Grants and funding

J.L. and Z.L. gratefully acknowledge funding from the Genome British Columbia Data Access, Integration and Analysis Program (award DAIA-008). ZL’s research is also supported by generous donations through the St. Paul’s Hospital Foundation.