Carbon Instrumentation in Patients with Metastatic Spinal Cord Compression

Cancers (Basel). 2024 Feb 9;16(4):736. doi: 10.3390/cancers16040736.

Abstract

Recently carbon spinal implants have been introduced in the treatment of patients with metastatic spinal cord compression (MSCC). This is expected to decrease the deflection of radiation and improve diagnostic imaging and radiotherapy when compared to titanium implants. The aim of this study was to determine the safety and effectiveness of spinal carbon instrumentation (CI) in patients with MSCC in a large cohort study. A total of 163 patients received instrumentation between 1 January 2017 and 31 December 2021. A total of 80 were stabilized with CI and 83 with TI. The outcome measures were surgical revision, postsurgical survival, peri-operative bleeding, and surgery time. The peri-operative blood loss in the CI-group was significantly lower than that in the TI-group: 450mL vs. 630mL, (p = 0.02). There were no significant differences between the groups in mean survival (CI 9.9) vs. (TI 12.9) months (p = 0.39), or the number of patients needing a revision (CI 6) vs. (TI 10), (p = 0.39). The median duration of surgery was 121 min, (p = 0.99) with no significant difference between the two groups. Surgical treatment with CI for MSCC is safe and an equally sufficient treatment when compared to TI.

Keywords: cancer treatment; metastatic spinal cord compression; spinal metastasis; spine surgery.

Grants and funding

This research received no direct external funding. Benny Dahl is supported by the Alfred Benzon foundation and is a consultant for Stryker. Martin Gehrchen received institutional grants from Cerapedics and Nuvasive.