Glycemic control in children with type 1 diabetes treated with the advanced hybrid closed loop system 2-year prospective, observational, two-center study

Sebastian Seget; Agata Chobot; Mateusz Tarasiewicz; Anna Bielawska; Ewa Rusak; Agnieszka Ochab; Joanna Polanska; Przemysława Jarosz-Chobot

doi:10.3389/fendo.2024.1332418

Glycemic control in children with type 1 diabetes treated with the advanced hybrid closed loop system 2-year prospective, observational, two-center study

Front Endocrinol (Lausanne). 2024 Feb 8:15:1332418. doi: 10.3389/fendo.2024.1332418. eCollection 2024.

Authors

Sebastian Seget¹, Agata Chobot², Mateusz Tarasiewicz¹, Anna Bielawska¹, Ewa Rusak¹, Agnieszka Ochab², Joanna Polanska³, Przemysława Jarosz-Chobot¹

Affiliations

¹ Department of Children's Diabetology, Medical University of Silesia, Katowice, Poland.
² Department of Pediatrics, Institute of Medical Sciences, University of Opole, Opole, Poland.
³ Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Poland.

Abstract

Background and aims: MiniMed 780G is the first Advanced Hybrid Closed Loop (AHCL) system in Poland, approved in the EU in 2020. To date, observations of glycemic control up to 12 months have been published. This study aimed to analyze glycemic control and anthropometric parameters in children and adolescents with type 1 diabetes (T1D) after two years of using the AHCL system.

Materials and methods: We prospectively collected anthropometric data, pump, and continuous glucose records of fifty T1D children (9.9 ± 2.4 years, 24 (48%) boys, T1D for 3.9 ± 2.56 years) using an AHCL system. We compared the two-week AHCL records obtained after AHCL enrollment with data 6, 12, and 24 months after starting AHCL.

Results: Time in range (70-180 mg/dl) and BMI z-score did not change during the 2 years of observation (p>0.05). The percentage of autocorrection in total daily insulin increased significantly (p<0.005).

Conclusion: Glycemic control in the investigated group of children with T1D treated with the AHCL system for 2 years remained stable. Children in this group maintained weight and optimal metabolic control, most likely due to autocorrection boluses.

Keywords: BMI; advanced hybrid closed-loop system; body mass index; children; time in range; type 1 diabetes.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Anthropometry
Body Fluids*
Child
Diabetes Mellitus, Type 1* / drug therapy
Female
Glycemic Control
Humans
Male
Prospective Studies

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. JP was financed by the Silesian University of Technology grant no 02/070/BK_23/0043 for Support and Development of Research Potential. SS was financed by Medical University of Silesia grant.