Long non-coding RNA (lncRNA) can affect the occurrence and development of diseases by directly or indirectly regulating target genes and their signal pathways. With the deepening of research, more and more lncRNA have been found to be involved in regulating the occurrence, development and drug resistance of multiple myeloma (MM). Therefore, it is necessary to study the role and molecular mechanism of abnormal expression of lncRNA in MM, which can provide theoretical basis for clinical diagnosis and targeted therapy.
题目: 长链非编码RNA在多发性骨髓瘤中的研究进展.
摘要: 长链非编码RNA（lncRNA）可通过直接或间接调控靶基因及其信号通路影响疾病的发生发展。随着研究的不断深入，越来越多的lncRNA被发现参与调控多发性骨髓瘤的发生、发展及耐药。因此，深入研究异常表达lncRNA在多发性骨髓瘤中的作用及其分子机制是十分必要的，可为临床诊断和靶向治疗提供理论依据。.
Keywords: multiple myeloma; drug resistance; long non-coding RNA.