Multiple myeloma (MM) is a hematologic neoplasm characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. NK cells, a class of innate lymphocytes with potent natural killer activity, are capable of recognizing and destroying tumor cells and virally infected cells, and have attracted attention as a potential anticancer therapy. In patients with MM, NK cells are suppressed in number and function, resulting in reduced immune surveillance and clearance of myeloma cells. Restoring or enhancing the killing effect of NK cells on myeloma cells is an important strategy for MM immunotherapy, and some progress has been made in clinical trials targeting NK cellrelated therapies. This article reviews the research progress on the applications prospects of NK cell in MM immunotherapy.
题目: NK细胞疗法在多发性骨髓瘤治疗中的研究进展.
摘要: . 多发性骨髓瘤（MM）是以骨髓中单克隆浆细胞的恶性增殖为特征的血液系统肿瘤。NK细胞是一类具有强大自然杀伤活性的先天性淋巴细胞，能够识别并消灭肿瘤细胞和病毒感染细胞，其作为潜在的抗癌疗法引起关注。在MM患者中，NK细胞的数量和功能均受到抑制，导致对骨髓瘤细胞的免疫监视和清除能力降低。恢复或增强NK细胞对骨髓瘤细胞的杀伤作用是MM免疫治疗的一个重要策略，目前针对NK细胞相关治疗在临床试验中取得了一定进展。本文对NK细胞在MM免疫治疗中应用前景的最新研究进展作一综述。.
Keywords: multiple myeloma; research progress; NK cell; hematopoietic microenvironment.