A Non-Bonding Interaction-Based Fluorescent Probe for Detection of Halogenated Carbonyl Compounds

Jinfei Deng; Jianyu Gu; Kaizhuo Lv; Xiaowei Du; Xiushen Ye; Chunyang He; Hongyu Li; Qiuli Yao

doi:10.1016/j.saa.2024.124018

A Non-Bonding Interaction-Based Fluorescent Probe for Detection of Halogenated Carbonyl Compounds

Spectrochim Acta A Mol Biomol Spectrosc. 2024 May 5:312:124018. doi: 10.1016/j.saa.2024.124018. Epub 2024 Feb 13.

Authors

Jinfei Deng¹, Jianyu Gu¹, Kaizhuo Lv¹, Xiaowei Du¹, Xiushen Ye², Chunyang He¹, Hongyu Li¹, Qiuli Yao³

Affiliations

¹ Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, Department of Pharmacy, Zunyi Medical University, 6 Xuefu Road West, Zunyi, 563000, China.
² Qinghai Provincial Key Laboratory of Resources and Chemistry of Salt Lakes, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, Qinghai, 810008, China.
³ Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, Department of Pharmacy, Zunyi Medical University, 6 Xuefu Road West, Zunyi, 563000, China; Qinghai Provincial Key Laboratory of Resources and Chemistry of Salt Lakes, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, Qinghai, 810008, China. Electronic address: yaoqiuli@zmu.edu.cn.

PMID: 38387410
DOI: 10.1016/j.saa.2024.124018

Abstract

The fluorescent detection of neutral and volatile carbonyl halogenated compounds had not been studied before. We describe here a simple and sensitive turn-on rhodamin fluorescent probe for the selective detection of fluorinated/brominated/chlorinated/iodinated carbonyl compounds. A wide range of linear or cyclic volatile organic halides was detected with a limit of detection as low as 45.6 nM within 1 min. Mechanistic experiments and DFT calculations indicate the reversible formation of a 1:1 complex of sensor and analyst through non-bonding interaction.

Keywords: Fluorescent probe; Halogenated compounds; Mechanism study; Quantitative analysis.