Case report: Gastric carcinoma with SMARCA4 deficient: two cases report and literature review

Zeyang Lin; Qian Li; Yujie He; Shujing Guo; Yuhan Ye; Zhengjin Liu

doi:10.3389/fonc.2024.1297140

Case report: Gastric carcinoma with SMARCA4 deficient: two cases report and literature review

Front Oncol. 2024 Feb 6:14:1297140. doi: 10.3389/fonc.2024.1297140. eCollection 2024.

Authors

Zeyang Lin¹, Qian Li¹, Yujie He², Shujing Guo¹, Yuhan Ye¹, Zhengjin Liu¹

Affiliations

¹ Department of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
² Lianqian Street Community Health Service Center, First Affiliated Hospital of Xiamen University, Xiamen, China.

Abstract

SMARCA4-deficient gastric carcinoma has been reported sporadically since 2016. Only 29 patients have been reported; nevertheless, it is aggressive and highly malignant with poor outcomes. It has an immunohistochemical phenotype showing loss of SMARCA4 expression and can be accompanied by codeletion of other switch/sucrose non-fermentable chromatin-remodeling complex subunits. Microscopically, it displays high-grade undifferentiated histological morphology with rhabdoid cell differentiation. Rarely does the tumor contain a purely or partly adenocarcinoma component. Here, we report two cases to demonstrate these unusual morphologies analyzed using morphological and immunohistochemical techniques. In addition, there is a lack of research on the classification of these morphologies. Therefore, our report will aid the diagnosis and classification of SMARCA4-deficient gastric carcinoma.

Keywords: SMARCA4; case; category; gastric carcinoma; therapy.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was carried out under the research program Natural Science Foundation of Xiamen City, 3502Z20227104, and Natural Science Foundation of Fujian Province, 2022J011338.