The association between growth differentiation factor 15 and presence and severity of coronary atherosclerosis

Abstract

Purpose: Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta superfamily and is faintly expressed under healthy conditions. GDF-15 is markedly elevated in a variety of diseases, including coronary artery disease (CAD), atrial fibrillation and heart failure. Here, we aimed to investigate the association of GDF-15 with the extent and severity of CAD in patients with stable CAD.

Methods: We enrolled 129 patients undergoing coronary angiography for the evaluation of stable CAD in the study. SYNTAX and SYNTAX II PCI/CABG scores were calculated. The CAD (+) study group was also stratified into two groups (high and low GDF-15) with respect to the mean GDF-15 value. Correlation and regression analyses were performed for further evaluation.

Results: Of the 129 patients, 75 had CAD. GDF-15 values were higher in the CAD (+) group (p ​< ​0.001). The two groups were compared according to a cut-off value of 2451.77. SYNTAX and SYNTAX II PCI/CABG scores were significantly associated with the high GDF-15 group (p ​< ​0.001). Additionally, correlation analysis showed a strong positive correlation between GDF-15 and SYNTAX (r: 0.859, p ​< ​0.001), SYNTAX II PCI (r: 0.921, p ​< ​0.001) and SYNTAX II CABG (r: 0.874, p ​< ​0.001) scores. Multivariate analysis identified GDF-15 as an independent predictor of CAD.

Conclusion: GDF-15 is an independent predictor of CAD and is associated with CAD severity in terms of SYNTAX, SYNTAX II PCI and SYNTAX II CABG scores.

Keywords: Coronary artery disease; GDF-15; SYNTAX II score; SYNTAX score.