Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis

Mohammed Kanan; Mohammed Naffaa; Ahmed Alanazi; Faiz Nasser; Ahad Amer Alsaiari; Mazen Almehmadi; Ali Assiry; Hisham Muzafar; Hejab Katam; Abdullah Arar; Syed Mohammed Basheeruddin Asdaq; Abida; Mohd Imran; Tafadzwa Dzinamarira

doi:10.1016/j.jiph.2024.02.001

Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis

J Infect Public Health. 2024 Apr;17(4):579-587. doi: 10.1016/j.jiph.2024.02.001. Epub 2024 Feb 3.

Authors

Affiliations

¹ Department of Clinical Pharmacy, King Fahad Medical City, Riyadh 12211, Saudi Arabia.
² Department of Forensic Toxicology, Poison Center, Arar, Northern Borders Region 73241, Saudi Arabia.
³ Poison Control and Forensic Chemistry Center, Arar, Northern Borders Region 73551, Saudi Arabia.
⁴ Department of Forensic Toxicology, Poison Center, Arar, Northern Borders Region 75861, Saudi Arabia.
⁵ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
⁶ Department of Medical Supply, Mohayil Hospital, Health Affairs of Aseer, Abha 63711, Saudi Arabia.
⁷ Department of Pharmacy, Jazan University Hospital, Jazan University, Jazan 82723, Saudi Arabia.
⁸ Department of Radiology, Extended Care Hospital, Arar, Northern Borders Region 73551, Saudi Arabia.
⁹ Public Health Department, Northern Border Regional Lab & Blood Bank, Arar, Northern Borders Region 73241, Saudi Arabia.
¹⁰ Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, 13713 Riyadh, Saudi Arabia.
¹¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
¹² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia. Electronic address: imran.pchem@gmail.com.
¹³ School of Health Systems and Public Health, University of Pretoria, Pretoria 0002, South Africa; ICAP, Columbia University, P.O. Box 28, Harare, Zimbabwe. Electronic address: u19395419@up.ac.za.

PMID: 38368646
DOI: 10.1016/j.jiph.2024.02.001

Abstract

Dengue hemorrhagic fever (DHF) is a severe condition resulting from the dengue virus, with four serotypes known as DEN-1, DEN-2, DEN-3, and DEN-4. Genetic variations play a crucial role in influencing susceptibility to DHF. Therefore, this investigation conducted a meta-analysis to uncover genetic changes that might have remained undetected in individual studies due to small sample sizes or methodological differences. Among 2212 initially identified studies, 23 were deemed suitable for analysis based on PRISMA guidelines. Toll-like receptors (TLR) and CD209 showed significant association with DHF (odds ratios: TLR=0.56, CD209 =0.55), indicating protective effects. However, tumor necrosis factor (TNF) and human leukocyte antigen (HLA) did not exhibit a statistically significant relationship with DHF. This study emphasizes the relevance of TLR and CD209 in DHF susceptibility and resistance across diverse geographical locations.

Keywords: Dengue virus; Human leukocyte antigen; Meta-analysis; Odd ratio; TNF toll-like receptors.

Publication types

Meta-Analysis
Systematic Review
Review

MeSH terms

Case-Control Studies
Dengue Virus* / genetics
Dengue* / genetics
Humans
Serogroup
Severe Dengue* / genetics
Tumor Necrosis Factor-alpha / genetics

Substances

Tumor Necrosis Factor-alpha