Epigenetic regulations of cellular senescence in osteoporosis

Shaochuan Huo; Xinzheng Tang; Weijian Chen; Donghao Gan; Hai Guo; Qing Yao; Rongdong Liao; Tingting Huang; Junxian Wu; Junxing Yang; Guozhi Xiao; Xia Han

doi:10.1016/j.arr.2024.102235

Epigenetic regulations of cellular senescence in osteoporosis

Ageing Res Rev. 2024 Feb 15:102235. doi: 10.1016/j.arr.2024.102235. Online ahead of print.

Authors

Shaochuan Huo¹, Xinzheng Tang¹, Weijian Chen², Donghao Gan³, Hai Guo⁴, Qing Yao³, Rongdong Liao⁵, Tingting Huang², Junxian Wu⁶, Junxing Yang⁷, Guozhi Xiao⁸, Xia Han⁹

Affiliations

¹ Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen 518000, China; Shenzhen Research Institute of Guangzhou University of Traditional Medicine (Futian), Shenzhen 518000, China.
² Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
³ Department of Biochemistry, School of Medicine, Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen 518055, China.
⁴ Liuzhou Traditional Chinese Medicine Hospital (Liuzhou Zhuang Medical Hospital), Liuzhou 545001, China.
⁵ Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
⁶ Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen 518000, China.
⁷ Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen 518000, China; Shenzhen Research Institute of Guangzhou University of Traditional Medicine (Futian), Shenzhen 518000, China. Electronic address: dryang@gzucm.edu.cn.
⁸ Department of Biochemistry, School of Medicine, Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address: xiaogz@sustech.edu.cn.
⁹ Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian), Shenzhen 518000, China; Shenzhen Research Institute of Guangzhou University of Traditional Medicine (Futian), Shenzhen 518000, China. Electronic address: 957848451@qq.com.

PMID: 38367814
DOI: 10.1016/j.arr.2024.102235

Abstract

Osteoporosis (OP) is a prevalent age-related disease that is characterized by a decrease in bone mineral density (BMD) and systemic bone microarchitectural disorders. With age, senescent cells accumulate and exhibit the senescence-associated secretory phenotype (SASP) in bone tissue, leading to the imbalance of bone homeostasis, osteopenia, changes in trabecular bone structure, and increased bone fragility. Cellular senescence in the bone microenvironment involves osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells (BMSCs), whose effects on bone homeostasis are regulated by epigenetics. Therefore, the epigenetic regulatory mechanisms of cellular senescence have received considerable attention as potential targets for preventing and treating osteoporosis. In this paper, we systematically review the mechanisms of aging-associated epigenetic regulation in osteoporosis, emphasizing the impact of epigenetics on cellular senescence, and summarize three current methods of targeting cellular senescence, which is helpful better to understand the pathogenic mechanisms of cellular senescence in osteoporosis and provides strategies for the development of epigenetic drugs for the treatment of osteoporosis.

Keywords: Cellular senescence; Epigenetic regulations; Osteoporosis; Pathogenic mechanism.

Publication types

Review