Skeletal muscle ageing: lessons from teleosts

Tuyen K Quach; Megan F Taylor; Peter D Currie; Nir Eynon; Avnika A Ruparelia

doi:10.1093/gerona/glae052

Skeletal muscle ageing: lessons from teleosts

J Gerontol A Biol Sci Med Sci. 2024 Feb 17:glae052. doi: 10.1093/gerona/glae052. Online ahead of print.

Authors

Tuyen K Quach^{1

2}, Megan F Taylor³, Peter D Currie^{3

4}, Nir Eynon³, Avnika A Ruparelia^{1

2

3}

Affiliations

¹ Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, 3010, Australia.
² Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, 3010, Australia.
³ Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, Victoria, 3800, Australia.
⁴ EMBL Australia, Victorian Node, Monash University, Clayton, Victoria, 3800, Australia.

PMID: 38367020
DOI: 10.1093/gerona/glae052

Abstract

Ageing is the greatest risk factor for a multitude of age-related diseases including sarcopenia -the loss of skeletal muscle mass and strength - which occurs at remarkable rates each year. There is an unmet need not only to understand the mechanisms that drive sarcopenia, but also to identify novel therapeutic strategies. Given the ease and affordability of husbandry, along with advances in genomics, genome editing technologies and imaging capabilities, teleost models are increasingly used for ageing and sarcopenia research. Here, we explain how teleost species such as zebrafish, African turquoise killifish and medaka recapitulate many of the classical hallmarks of sarcopenia, and discuss the various dietary, pharmacological and genetic approaches that have been used in teleosts to understand the mechanistic basis of sarcopenia.