Project NexGen: Developing the Next Generation of COVID-19 Vaccines and Therapeutics to Respond to the Present and Prepare for the Future

Kimberly A Hofmeyer; Christy L Ventura; Project NextGen Line of Effort Leads; Kimberly L Armstrong; Christopher R Houchens; Sandeep Patel; Gary L Disbrow; Robert A Johnson

doi:10.1093/cid/ciae073

Project NexGen: Developing the Next Generation of COVID-19 Vaccines and Therapeutics to Respond to the Present and Prepare for the Future

Clin Infect Dis. 2024 Feb 13:ciae073. doi: 10.1093/cid/ciae073. Online ahead of print.

Authors

Kimberly A Hofmeyer¹, Christy L Ventura¹; Project NextGen Line of Effort Leads; Kimberly L Armstrong¹, Christopher R Houchens¹, Sandeep Patel¹, Gary L Disbrow¹, Robert A Johnson¹

Collaborators

Project NextGen Line of Effort Leads:
Aaron C Bandremer, John H Beigel, Timothy T Belski, Ruben O Donis, Lakshmi Jayashankar, Richard A Koup, Gerald R Kovacs, Malen A Link, Karen A Martins, Robin M Mason, Sabrina M Stronsky, Daniel N Wolfe

Affiliation

¹ Biomedical Advanced Research and Development Authority, Administration for Strategic Preparedness and Response, U.S. Department of Health and Human Services.

PMID: 38356144
DOI: 10.1093/cid/ciae073

Abstract

COVID-19 epidemiology and product landscapes have changed considerably since onset of the pandemic. Safe and effective vaccines and therapeutics are available, but the continual emergence of SARS-CoV-2 variants introduce limitations in our ability to prevent and treat disease. Project NextGen is a collaboration between the Biomedical Advanced Research and Development Authority (BARDA), part of the Administration for Strategic Preparedness and Response (ASPR), and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, that is leveraging public-private partnerships to address gaps in the nation's COVID-19 vaccine and therapeutic capabilities. Targeted investments will advance promising next-generation candidates through the most difficult phases of clinical development to encourage further private sector interest for later stage development and commercial availability. New commercial vaccines and therapeutics that are more durable and effective across variants will improve our fight against COVID-19 and transform our response to future threats.

Keywords: COVID-19; COVID-19 Vaccines; COVID-19 therapeutics; medical countermeasures; pandemic preparedness.