Linearity and bias of proton density fat fraction across the full dynamic range of 0-100%: a multiplatform, multivendor phantom study using 1.5T and 3T MRI at two sites

Houchun H Hu; Henry Szu-Meng Chen; Diego Hernando

doi:10.1007/s10334-024-01148-9

Linearity and bias of proton density fat fraction across the full dynamic range of 0-100%: a multiplatform, multivendor phantom study using 1.5T and 3T MRI at two sites

MAGMA. 2024 Feb 13. doi: 10.1007/s10334-024-01148-9. Online ahead of print.

Authors

Houchun H Hu^{1

2}, Henry Szu-Meng Chen^{3

4}, Diego Hernando^{5

6}

Affiliations

¹ Department of Radiology, Section of Radiological Science, Anschutz School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Leprino Building, 12401 E 17th Ave, 5th Floor, Mail Stop L954, Aurora, CO, 80045, USA. houchun.hu@cuanschutz.edu.
² Department of Radiology, Children's Hospital Colorado, Aurora, CO, USA. houchun.hu@cuanschutz.edu.
³ Department of Radiology, Section of Radiological Science, Anschutz School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Leprino Building, 12401 E 17th Ave, 5th Floor, Mail Stop L954, Aurora, CO, 80045, USA.
⁴ Department of Radiology, Children's Hospital Colorado, Aurora, CO, USA.
⁵ Department of Radiology, University of Wisconsin, Madison, WI, USA.
⁶ Department of Medical Physics, University of Wisconsin, Madison, WI, USA.

PMID: 38349454
DOI: 10.1007/s10334-024-01148-9

Abstract

Objective: Performance assessments of quantitative determinations of proton density fat fraction (PDFF) have largely focused on the range between 0 and 50%. We evaluate PDFF in a two-site phantom study across the full 0-100% PDFF range.

Materials and methods: We used commercially available 3D chemical-shift-encoded water-fat MRI sequences from three MRI system vendors at 1.5T and 3T and conducted the study across two sites. A spherical phantom housing 18 vials spanning the full 0-100% PDFF range was used. Data at each site were acquired using default parameters to determine same-day and different-day intra-scanner repeatability, and inter-system and inter-site reproducibility, in addition to linear regression between reference and measured PDFF values.

Results: Across all systems, results demonstrated strong linearity and minimal bias. For 1.5T systems, a pooled slope of 0.99 with a 95% confidence interval (CI) of 0.981-0.997 and a pooled intercept of 0.61% PDFF with a 95% CI of 0.17-1.04 were obtained. Results for pooled 3T data included a slope of 1.00 (95% CI 0.995-1.005) and an intercept of 0.69% PDFF (95% CI 0.39-0.97). Inter-site and inter-system reproducibility coefficients ranged from 2.9 to 6.2 (in units of PDFF), while intra-scanner same-day and different-day repeatability ranged from 0.6 to 7.8.

Discussion: PDFF across the 0-100% range can be reliably estimated using current commercial offerings at 1.5T and 3T.

Keywords: Multi-center; Multi-vendor; Proton density fat fraction; Quantitative; Repeatability; Reproducibility.

Abstract

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