Recent advances in the study of knockdown resistance mutations in Aedes mosquitoes with a focus on several remarkable mutations

Nozomi Uemura; Kentaro Itokawa; Osamu Komagata; Shinji Kasai

doi:10.1016/j.cois.2024.101178

Recent advances in the study of knockdown resistance mutations in Aedes mosquitoes with a focus on several remarkable mutations

Curr Opin Insect Sci. 2024 Feb 10:63:101178. doi: 10.1016/j.cois.2024.101178. Online ahead of print.

Authors

Nozomi Uemura¹, Kentaro Itokawa¹, Osamu Komagata¹, Shinji Kasai²

Affiliations

¹ Department of Medical Entomology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
² Department of Medical Entomology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan. Electronic address: kasacin@niid.go.jp.

PMID: 38346494
DOI: 10.1016/j.cois.2024.101178

Abstract

The Aedes mosquito, which transmits the dengue fever virus and other viruses, has acquired resistance to pyrethroid insecticides in a naturally selective manner. Massive use of insecticides has led to the worldwide expansion of resistant populations. The major factor in pyrethroid resistance is knockdown resistance (kdr) caused by amino acid mutation(s) in the voltage-gated sodium channel, which is the target site of this insecticide group. Some kdr mutations can lead to a dramatic increase in resistance, and multiple mutations can increase the level of pyrethroid resistance by 10 to several-hundred. In this review, we summarize the kdr identified in Aedes mosquitoes with a focus on the recent advances in the study of kdr.

Publication types

Review