Gestational Diabetes Mellitus, Obstetric Data, and Simple Congenital Ptosis

Konstantin Gushansky; Achia Nemet; Raimo Tuuminen

doi:10.1097/IOP.0000000000002629

Gestational Diabetes Mellitus, Obstetric Data, and Simple Congenital Ptosis

Ophthalmic Plast Reconstr Surg. 2024 Feb 12. doi: 10.1097/IOP.0000000000002629. Online ahead of print.

Authors

Konstantin Gushansky¹, Achia Nemet², Raimo Tuuminen^{3

4

5}

Affiliations

¹ Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel.
² Department of Ophthalmology, Assuta Medical Center, Ashdod, Israel.
³ Department of Ophthalmology, Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.
⁴ Department of Ophthalmology, Kymenlaakso Central Hospital, Kotka, Finland.
⁵ Department of Ophthalmology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

PMID: 38346430
DOI: 10.1097/IOP.0000000000002629

Abstract

Purpose: This retrospective cohort study aimed to identify obstetric risk factors for simple congenital ptosis and propose an underlying pathophysiological mechanism.

Methods: Newborns diagnosed with simple congenital ptosis (n = 51) were compared with existing population data in terms of obstetric parameters.

Results: Positive associations were found between simple congenital ptosis and gestational diabetes mellitus (11.8% vs. 5%, p = 0.026), preterm delivery (15.7% vs. 0.05%, p < 0.001), and lower birth weight (2,998 ± 506 vs. 3,255 ± 484, p < 0.001).

Conclusions: This study pioneers an association between simple congenital ptosis and gestational diabetes mellitus, potentially linked to insulin-like growth factor 1 levels. We advocate for early ophthalmology checkups for specific newborn subsets.