Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review

Md Sadique Hussain; Obaid Afzal; Gaurav Gupta; Ahsas Goyal; Waleed Hassan Almalki; Imran Kazmi; Sami I Alzarea; Abdulmalik Saleh Alfawaz Altamimi; Neelam Kukreti; Amlan Chakraborty; Sachin Kumar Singh; Kamal Dua

doi:10.17179/excli2023-6553

Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review

EXCLI J. 2024 Jan 3:23:34-52. doi: 10.17179/excli2023-6553. eCollection 2024.

Authors

Md Sadique Hussain¹, Obaid Afzal², Gaurav Gupta^{3

4}, Ahsas Goyal⁵, Waleed Hassan Almalki⁶, Imran Kazmi⁷, Sami I Alzarea⁸, Abdulmalik Saleh Alfawaz Altamimi², Neelam Kukreti⁹, Amlan Chakraborty^{10

11}, Sachin Kumar Singh^{12

13}, Kamal Dua^{13

14}

Affiliations

¹ School of Pharmaceutical Sciences, Jaipur National University, Jagatpura 302017, Jaipur, India.
² Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia.
³ School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India.
⁴ Centre for Transdisciplinary Research, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India.
⁵ Institute of Pharmaceutical Research, GLA University, Mathura, U. P., India.
⁶ Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
⁷ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
⁸ Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
⁹ School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India.
¹⁰ Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.
¹¹ Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC 3800, Australia.
¹² School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
¹³ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.
¹⁴ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia.

Abstract

This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC. See also the Graphical abstract(Fig. 1).

Keywords: NEAT1; cancer; clinical applications; long non-coding RNA; lung cancer.

Publication types

Review