Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease

Jinling Li; Ting Luo; Dou Wang; Yao Zhao; Yuanxiang Jin; Guiling Yang; Xin Zhang

doi:10.1016/j.jare.2024.01.035

Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease

J Adv Res. 2024 Feb 9:S2090-1232(24)00047-X. doi: 10.1016/j.jare.2024.01.035. Online ahead of print.

Authors

Jinling Li¹, Ting Luo², Dou Wang², Yao Zhao³, Yuanxiang Jin⁴, Guiling Yang⁵, Xin Zhang⁶

Affiliations

¹ Department of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang Province, China; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, China.
² State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, China.
³ Biomanufacturing Research Institute of Xianghu Laboratory, Hangzhou 311231, Zhejiang Province, China.
⁴ Biomanufacturing Research Institute of Xianghu Laboratory, Hangzhou 311231, Zhejiang Province, China; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, Zhejiang Province, China.
⁵ State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, China; Biomanufacturing Research Institute of Xianghu Laboratory, Hangzhou 311231, Zhejiang Province, China. Electronic address: guilingchina2008@163.com.
⁶ Department of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang Province, China. Electronic address: zhangxin@nbu.edu.cn.

PMID: 38341033
DOI: 10.1016/j.jare.2024.01.035

Abstract

Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies.

Aim of review: This review summarizes the recent advances and potential mechanisms underlying PDEVs obtained from different sources to alleviate IBD. In addition, the review discusses the possible applications and challenges of PDEVs, providing a theoretical basis for exploring novel and practical therapeutic strategies for IBD.

Key scientific concepts of review: In IBD, the crosstalk mechanism of PDEVs may regulate the intestinal microenvironment homeostasis, especially immune responses, the intestinal barrier, and the gut microbiota. In addition, drug loading enhances the therapeutic potential of PDEVs, particularly regarding improved tissue targeting and stability. In the future, not only immunotherapy based on PDEVs may be an effective treatment for IBD, but also the intestinal barrier and intestinal microbiota will be a new direction for the treatment of IBD.

Keywords: Gut microbiota; Immune response; Inflammatory bowel disease; Intestinal barrier; Plant-derived extracellular vesicles.

Publication types

Review