Nodal metastasis in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Alfredo Campennì; Liborio Torregrossa; Rosaria Maddalena Ruggeri; Petra Petranović Ovčariček; Massimiliano Siracusa; Luca Giovanella

doi:10.1007/s12020-024-03719-1

Nodal metastasis in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Endocrine. 2024 Feb 10. doi: 10.1007/s12020-024-03719-1. Online ahead of print.

Authors

Alfredo Campennì¹, Liborio Torregrossa², Rosaria Maddalena Ruggeri³, Petra Petranović Ovčariček^{4

5}, Massimiliano Siracusa⁶, Luca Giovanella⁷

Affiliations

¹ Unit of Nuclear Medicine, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy. acampenni@unime.it.
² Department of Surgical, Medical, Molecular Pathology and Clinical Area, University of Pisa, Pisa, Italy.
³ Department of Human Pathology of Adulthood and Childhood DETEV "G. Barresi", Endocrinology Unit, University of Messina, 98125, Messina, Italy.
⁴ Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
⁵ School of Medicine, University of Zagreb, Zagreb, Croatia.
⁶ Unit of Nuclear Medicine, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy.
⁷ Clinic for Nuclear Medicine, University Hospital and University of Zurich, Zurich, Switzerland.

PMID: 38340243
DOI: 10.1007/s12020-024-03719-1

Abstract

The term noninvasive tumor with a follicular growth pattern and nuclear features of papillary thyroid cancer (NIFTP) is used to describe a tumor currently considered as a pre-malignant lesion for which a conservative therapeutic approach (i.e., lobectomy without radioiodine therapy) is strongly suggested. However, some patients with NIFTP and loco-regional or distant metastases have been already reported. We present an adult male patient with a final histological diagnosis of NIFTP and lymph node metastasis noted at post-therapy whole-body scintigraphy performed some days after radioiodine therapy.

Keywords: Iodine-131 therapy; Lobectomy; Lymph node metastasis; NIFTP.