Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus

Zihuan Sang; Yanjiang Zhang; Kaidi Qiu; Yuting Zheng; Chen Chen; Li Xu; Jiaying Lai; Zhenxing Zou; Haibo Tan

doi:10.3390/molecules29030649

Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus

Molecules. 2024 Jan 30;29(3):649. doi: 10.3390/molecules29030649.

Authors

Zihuan Sang^{1

2

3}, Yanjiang Zhang³, Kaidi Qiu³, Yuting Zheng¹, Chen Chen^{1

2

3}, Li Xu¹, Jiaying Lai³, Zhenxing Zou¹, Haibo Tan^{1

2

3}

Affiliations

¹ Hunan Key Laboratory of Diagnostic and Therapeutic Drug Rsearch for Chronic Diseases, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
² National Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou 341000, China.
³ Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.

Abstract

A new bergamotane sesquiterpenoid, named xylariterpenoid H (1), along with fourteen known compounds (2-15), were isolated from the crude extract of Aspergillus fumigatus, an endophytic fungus isolated from Delphinium grandiflorum L. Their structures were elucidated mainly by extensive analyses of NMR and MS spectroscopic data. In addition, the screening results of antibacterial and cytotoxic activities of compounds 1-15 showed that compound 4 displayed antibacterial activities against Staphylococcus aureus and MRSA (methicillin-resistant S. aureus) with an MIC value of 3.12 µg/mL.

Keywords: Aspergillus fumigatus; MRSA; antibacterial activity; sesquiterpenoid.

MeSH terms

Anti-Bacterial Agents / chemistry
Aspergillus fumigatus*
Fungi
Methicillin-Resistant Staphylococcus aureus*
Microbial Sensitivity Tests
Molecular Structure

Substances

Anti-Bacterial Agents

Abstract

MeSH terms

Substances

Grants and funding