The Impact of a Single Haemodialysis Session on the Retinal Thickness and Optic Nerve Morphology

Joanna Roskal-Wałek; Joanna Gołębiewska; Jerzy Mackiewicz; Agnieszka Bociek; Paweł Wałek; Michał Biskup; Kamila Bołtuć-Dziugieł; Katarzyna Starzyk; Dominik Odrobina; Beata Wożakowska-Kapłon; Andrzej Jaroszyński

doi:10.3390/diagnostics14030331

The Impact of a Single Haemodialysis Session on the Retinal Thickness and Optic Nerve Morphology

Diagnostics (Basel). 2024 Feb 3;14(3):331. doi: 10.3390/diagnostics14030331.

Authors

Joanna Roskal-Wałek^{1

2}, Joanna Gołębiewska^{3

4}, Jerzy Mackiewicz⁵, Agnieszka Bociek², Paweł Wałek^{2

6}, Michał Biskup¹, Kamila Bołtuć-Dziugieł², Katarzyna Starzyk^{2

6}, Dominik Odrobina^{2

7}, Beata Wożakowska-Kapłon^{2

6}, Andrzej Jaroszyński²

Affiliations

¹ Ophthalmology Clinic, Voivodeship Regional Hospital, 25-736 Kielce, Poland.
² Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland.
³ Department of Ophthalmology, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland.
⁴ Medical Faculty, Lazarski University, 02-662 Warsaw, Poland.
⁵ Department of Vitreoretinal Surgery, Medical University of Lublin, 20-079 Lublin, Poland.
⁶ 1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre, 25-736 Kielce, Poland.
⁷ Ophthalmology Clinic Boni Fratres Lodziensis, 93-357 Łódź, Poland.

Abstract

Background: The aim of the study was to assess the influence of a single haemodialysis (HD) session on the retinal and optic nerve morphology in end-stage kidney disease (ESKD) patients.

Methods: It is a prospective study including only the right eye of 35 chronic kidney disease (CKD) patients subjected to HD. Each patient underwent a full eye examination 30 min before HD (8 a.m.) and 15 min after HD. Optical coherence tomography (OCT) was used to assess the peripapillary retinal nerve fibre layer (pRNFL) thickness, macular nerve fibre layer (mRNFL) thickness, ganglion cell layer with inner plexiform layer thickness (GCL+), GCL++ (mRNFL and GCL+) thickness, total retinal thickness (RT) and total macular volume (TMV). The correlation was tested between such systemic parameters changes as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), body weight, plasma osmolarity and ocular perfusion pressure (OPP) and ultrafiltration volume with total RT and pRNFL thickness changes during HD.

Results: In the results of a single HD session, we could observe a statistically significant increase in the total RT thickness (pre-HD 270.4 ± 19.94 μm, post-HD 272.14 ± 20.11 μm; p = 0.0014), TMV (pre-HD 7.48 ± 0.53 mm³, post-HD 7.52 ± 0.55 mm³; p = 0.0006), total pRNFL thickness (pre-HD 97.46 ± 15.71 μm, post-HD 100.23 ± 14.7 μm; p = 0.0039), total GCL+ thickness (pre-HD 70.11 ± 9.24 μm, post-HD 70.6 ± 9.7 μm; p = 0.0044), and GCL++ thickness (pre-HD 97.46 ± 12.56 μm, post-HD 97.9 ± 12.94 μm; p = 0.0081). We observed a significant correlation between the change in total RT and DBP change, as well as between body weight change and the change in total pRNFL thickness. There was also a correlation between total pRNFL thickness change and the presence of diabetes mellitus.

Conclusion: Even a single HD session affects the retinal and pRNFL thickness, which should be taken into account when interpreting the OCT results in patients subjected to HD. The impact of changes after a single HD session on selected parameters requires further assessment in subsequent studies, including long-term observation.

Keywords: haemodialysis; optical coherence tomography; retinal thickness.

Abstract

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