Ibrutinib-associated focal segmental glomerulosclerosis and the impact of podocin mutations in chronic lymphocytic leukemia

Kidney Int. 2024 Apr;105(4):877-881. doi: 10.1016/j.kint.2024.02.001. Epub 2024 Feb 8.
No abstract available

Keywords: FSGS; R229Q; ibrutinib; nephrotic syndrome; podocin.

MeSH terms

  • Adenine / analogs & derivatives*
  • Glomerulosclerosis, Focal Segmental* / chemically induced
  • Glomerulosclerosis, Focal Segmental* / drug therapy
  • Glomerulosclerosis, Focal Segmental* / genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
  • Membrane Proteins*
  • Mutation
  • Nephrotic Syndrome* / genetics
  • Piperidines*

Substances

  • NPHS2 protein
  • ibrutinib
  • Adenine
  • Membrane Proteins
  • Piperidines
  • Intracellular Signaling Peptides and Proteins