Vertebral Bone Quality Score as a Predictor of Adjacent Segment Disease After Lumbar Interbody Fusion

Cathleen C Kuo; Mohamed A R Soliman; Rehman Ali Baig; Alexander O Aguirre; Nicco Ruggiero; Brianna M Donnelly; Manhal Siddiqi; Asham Khan; Esteban Quiceno; Jeffrey P Mullin; John Pollina

doi:10.1227/neu.0000000000002864

Vertebral Bone Quality Score as a Predictor of Adjacent Segment Disease After Lumbar Interbody Fusion

Neurosurgery. 2024 Feb 9. doi: 10.1227/neu.0000000000002864. Online ahead of print.

Authors

Cathleen C Kuo¹, Mohamed A R Soliman^{2

3

4}, Rehman Ali Baig^{2

3}, Alexander O Aguirre¹, Nicco Ruggiero¹, Brianna M Donnelly³, Manhal Siddiqi¹, Asham Khan^{2

3}, Esteban Quiceno^{2

3}, Jeffrey P Mullin^{1

2

3}, John Pollina^{1

2

3}

Affiliations

¹ Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, New York, USA.
² Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, New York, USA.
³ Department of Neurosurgery, Buffalo General Medical Center, Kaleida Health, Buffalo, New York, USA.
⁴ Department of Neurosurgery, Faculty of Medicine, Cairo University, Cairo, Egypt.

PMID: 38334396
DOI: 10.1227/neu.0000000000002864

Abstract

Background and objective: With lumbar spine fusion being one of the most commonly performed spinal surgeries, investigating common complications such as adjacent segment disease (ASD) is a high priority. To the authors' knowledge, there are no previous studies investigating the utility of the preoperative magnetic resonance imaging-based vertebral bone quality (VBQ) score in predicting radiographic and surgical ASD after lumbar spine fusion. We aimed to investigate the predictive factors for radiographic and surgical ASD, focusing on the predictive potential of the VBQ score.

Methods: A single-center retrospective analysis was conducted of all patients who underwent 1-3 level lumbar or lumbosacral interbody fusion for lumbar spine degenerative disease between 2014 and 2021 with a minimum 12 months of clinical and radiographic follow-up. Demographic data were collected, along with patient medical, and surgical data. Preoperative MRI was assessed in the included patients using the VBQ scoring system to identify whether radiographic ASD or surgical ASD could be predicted.

Results: A total of 417 patients were identified (mean age, 59.8 ± 12.4 years; women, 54.0%). Eighty-two (19.7%) patients developed radiographic ASD, and 58 (13.9%) developed surgical ASD. A higher VBQ score was a significant predictor of radiographic ASD in univariate analysis (2.4 ± 0.5 vs 3.3 ± 0.4; P < .001) and multivariate analysis (odds ratio, 1.601; 95% CI, 1.453-1.763; P < .001). For surgical ASD, a significantly higher VBQ score was seen in univariate analysis (2.3 ± 0.5 vs 3.3 ± 0.4; P < .001) and served as an independent risk factor in multivariate analysis (odds ratio, 1.509; 95% CI, 1.324-1.720; P < .001). We also identified preoperative disk bulge and preoperative existence of adjacent segment disk degeneration to be significant predictors of both radiographic and surgical ASD. Furthermore, 3-level fusion was also a significant predictor for surgical ASD.

Conclusion: The VBQ scoring system might be a useful adjunct for predicting radiographic and surgical ASD.