Fatal invasive pulmonary and cerebral aspergillosis due to triazole-resistant Aspergillus fumigatus with multiple CYP51A mutations

J Antimicrob Chemother. 2024 May 2;79(5):1191-1192. doi: 10.1093/jac/dkae038.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antifungal Agents* / pharmacology
  • Antifungal Agents* / therapeutic use
  • Aspergillus fumigatus* / drug effects
  • Aspergillus fumigatus* / genetics
  • Aspergillus fumigatus* / isolation & purification
  • Cytochrome P-450 Enzyme System* / genetics
  • Drug Resistance, Fungal* / genetics
  • Fatal Outcome
  • Fungal Proteins* / genetics
  • Humans
  • Invasive Pulmonary Aspergillosis / drug therapy
  • Invasive Pulmonary Aspergillosis / microbiology
  • Male
  • Microbial Sensitivity Tests
  • Mutation*
  • Neuroaspergillosis / drug therapy
  • Neuroaspergillosis / genetics
  • Neuroaspergillosis / microbiology
  • Triazoles* / pharmacology
  • Triazoles* / therapeutic use

Substances

  • Antifungal Agents
  • cytochrome P-450 CYP51A, Aspergillus
  • Cytochrome P-450 Enzyme System
  • Fungal Proteins
  • Triazoles