Clinical research on RSV prevention in children and pregnant women: progress and perspectives

Xuejia Gong; Erdan Luo; Li Fan; Wanggang Zhang; Yan Yang; Yuhua Du; Xiao Yang; Shasha Xing

doi:10.3389/fimmu.2023.1329426

Clinical research on RSV prevention in children and pregnant women: progress and perspectives

Front Immunol. 2024 Jan 24:14:1329426. doi: 10.3389/fimmu.2023.1329426. eCollection 2023.

Authors

Xuejia Gong^#¹, Erdan Luo^#¹, Li Fan¹, Wanggang Zhang¹, Yan Yang², Yuhua Du³, Xiao Yang¹, Shasha Xing¹

Affiliations

¹ Good Clinical Practice Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
² Medical Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
³ Obstetrical Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

^# Contributed equally.

Abstract

Respiratory syncytial virus (RSV) is a significant causative agent of bronchitis and pneumonia in infants and children. The identification and structural analysis of the surface fusion glycoprotein of RSV represents a pivotal advancement in the development of RSV prevention. This review provides a comprehensive summary of RSV monoclonal antibody (mAb) and vaccine clinical trials registered on ClinicalTrials.gov, emphasizing on the classification, name, target, phase, clinical outcomes, and safety data of RSV vaccination in newborns, infants and children. We also discuss the characteristics of the types of RSV vaccines for maternal immunity and summarize the current clinical research progress of RSV vaccination in pregnant women and their protective efficacy in infants. This review will provide new ideas for the development of RSV prevention for children in the future.

Keywords: RSV vaccines; children; clinical trial; monoclonal antibody; pregnant women.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
Child
Female
Humans
Infant
Infant, Newborn
Pregnancy
Pregnant Women
Respiratory Syncytial Virus Infections*
Respiratory Syncytial Virus Vaccines*
Respiratory Syncytial Virus, Human*
Vaccination

Substances

Respiratory Syncytial Virus Vaccines
Antibodies, Viral

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study received financial support from the National Natural Science Foundation of China (Grant NO.82100475), Sichuan Science and Technology Program (Grant NO. 2023NSFSC0617, 2022YFS0227), Chengdu Women’s and Children’s Central Hospital Talent Program (Grant NO. YC2021003, YC2022002), and Technology Bureau of Chengdu (Grant NO. NO2020-YF05-00145-SN).