Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure

NEJM Evid. 2024 Feb;3(2):EVIDoa2300286. doi: 10.1056/EVIDoa2300286. Epub 2023 Nov 11.

Abstract

Dapagliflozin in Myocardial InfarctionA total of 4017 patients with acute myocardial infarction, but no diabetes or chronic heart failure, were randomly assigned 10 mg of dapagliflozin or placebo. The primary outcome was a composite of death, hospitalization for heart failure, and five cardiometabolic outcomes analyzed using the win ratio method. There were significantly more wins for dapagliflozin than for placebo (win ratio, 1.34; 95% confidence interval, 1.20 to 1.50), which was driven by the cardiometabolic outcomes. The composite of time to cardiovascular death/hospitalization for heart failure was not different between the two groups.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Benzhydryl Compounds*
  • Diabetes Mellitus, Type 2* / drug therapy
  • Glucosides*
  • Heart Failure* / drug therapy
  • Humans
  • Myocardial Infarction* / drug therapy
  • Sodium-Glucose Transporter 2 Inhibitors* / therapeutic use

Substances

  • dapagliflozin
  • Sodium-Glucose Transporter 2 Inhibitors
  • Benzhydryl Compounds
  • Glucosides