Vemurafenib and Obinutuzumab as Frontline Therapy for Hairy Cell Leukemia

NEJM Evid. 2023 Oct;2(10):EVIDoa2300074. doi: 10.1056/EVIDoa2300074. Epub 2023 Sep 21.

Abstract

Vemurafenib and Obinutuzumab for Hairy Cell LeukemiaIn this study of vemurafenib plus obinutuzumab of patients with previously untreated hairy cell leukemia, treatment was administered for four cycles, and the primary end point was complete remission rate. Twenty-seven of 30 patients completed all four cycles of treatment and achieved complete remission. No dose-limiting toxicity was observed.

MeSH terms

  • Antibodies, Monoclonal, Humanized / adverse effects
  • Humans
  • Leukemia, Hairy Cell* / chemically induced
  • Remission Induction
  • Vemurafenib

Substances

  • Vemurafenib
  • obinutuzumab
  • Antibodies, Monoclonal, Humanized