Lung Function of Preterm Children Parsed by a Polygenic Risk Score for Adult COPD

Gyde Nissen; Svenja Hinsenbrock; Tanja K Rausch; Guido Stichtenoth; Isabell Ricklefs; Markus Weckmann; Andre Franke; Egbert Herting; Inke R König; Matthias V Kopp; Klaus F Rabe; Wolfgang Göpel

doi:10.1056/EVIDoa2200279

Lung Function of Preterm Children Parsed by a Polygenic Risk Score for Adult COPD

NEJM Evid. 2023 Mar;2(3):EVIDoa2200279. doi: 10.1056/EVIDoa2200279. Epub 2023 Feb 24.

Authors

Gyde Nissen^{1

2}, Svenja Hinsenbrock¹, Tanja K Rausch³, Guido Stichtenoth¹, Isabell Ricklefs^{1

2}, Markus Weckmann^{1

2

4}, Andre Franke⁵, Egbert Herting¹, Inke R König^{2

3}, Matthias V Kopp^{2

6}, Klaus F Rabe^{2

7}, Wolfgang Göpel¹

Affiliations

¹ Department of Pediatrics, University Hospital Schleswig-Holstein, University of Lübeck, Lübeck, Germany.
² Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Grosshansdorf, Germany.
³ Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.
⁴ Epigenetics of Chronic Lung Disease, Priority Research Area Chronic Lung Diseases, Leibniz Lung Research Center Borstel, Borstel, Germany.
⁵ Institute of Clinical and Molecular Biology, University Hospital Schleswig-Holstein, Christian Albrechts-University, Kiel, Germany.
⁶ Department of Paediatric Respiratory Medicine, Inselspital Bern, University Children's Hospital of Bern, Bern, Switzerland.
⁷ LungenClinic Grosshansdorf, Grosshansdorf, and Department of Medicine, University Hospital Schleswig Holstein, University of Kiel, Kiel, Germany.

PMID: 38320054
DOI: 10.1056/EVIDoa2200279

Abstract

Lung Function of Preterm Children by COPD PRSPolygenic risk score (PRS) for FEV₁ and FVC was calculated in children born prematurely. COPD risk score was strongly associated with FEV₁ (-0.05 z score/decile, P=6.5 × 10^-9) and FEV₁/FVC (-0.07 z score/decile, P=4.4 × 10^-11) but not FVC. Children at highest risk had lower lung function by these measures and higher rates of obstructive bronchitis.

MeSH terms

Adult
Child
Forced Expiratory Volume
Genetic Risk Score
Humans
Infant, Newborn
Lung
Pulmonary Disease, Chronic Obstructive*
Risk Factors