What Is the Best Oral Therapy for Staph aureus Osteomyelitis?

NEJM Evid. 2022 Nov;1(11):EVIDtt2200119. doi: 10.1056/EVIDtt2200119. Epub 2022 Oct 25.

Abstract

Best Oral Therapy for Staph aureus OsteomyelitisA 50-year-old patient with diabetes mellitus has a plantar ulcer at the base of the first metatarsal. Cortical erosions are noted; bone biopsy culture yields Staphylococcus aureus susceptible to methicillin, ciprofloxacin, clindamycin, doxycycline, trimethoprim/sulfamethoxazole, linezolid, and rifampin. The plan is for 4 weeks of antibiotic treatment. Which antibiotic should be prescribed?

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Clindamycin
  • Humans
  • Methicillin-Resistant Staphylococcus aureus*
  • Middle Aged
  • Osteomyelitis* / drug therapy
  • Staphylococcal Infections* / drug therapy
  • Staphylococcus aureus

Substances

  • Anti-Bacterial Agents
  • Clindamycin