Hypothermic versus Normothermic Temperature Control after Cardiac Arrest

Johan Holgersson; Martin Abild Stengaard Meyer; Josef Dankiewicz; Gisela Lilja; Susann Ullén; Christian Hassager; Tobias Cronberg; Matt P Wise; Jan Bělohlávek; Jan Hovdenes; Paolo Pelosi; David Erlinge; Claudia Schrag; Ondrej Smid; Iole Brunetti; Christian Rylander; Paul J Young; Manoj Saxena; Anders Åneman; Alain Cariou; Clifton Callaway; Glenn M Eastwood; Matthias Haenggi; Michael Joannidis; Thomas R Keeble; Hans Kirkegaard; Christoph Leithner; Helena Levin; Alistair D Nichol; Matt P G Morgan; Per Nordberg; Mauro Oddo; Christian Storm; Fabio Silvio Taccone; Matthew Thomas; John Bro-Jeppesen; Janneke Horn; Jesper Kjaergaard; Michael Kuiper; Tommaso Pellis; Pascal Stammet; Michael Jaeger Wanscher; Hans Friberg; Niklas Nielsen; Janus Christian Jakobsen

doi:10.1056/EVIDoa2200137

Hypothermic versus Normothermic Temperature Control after Cardiac Arrest

NEJM Evid. 2022 Nov;1(11):EVIDoa2200137. doi: 10.1056/EVIDoa2200137. Epub 2022 Jun 15.

Authors

Johan Holgersson¹, Martin Abild Stengaard Meyer², Josef Dankiewicz³, Gisela Lilja⁴, Susann Ullén⁵, Christian Hassager², Tobias Cronberg⁴, Matt P Wise⁶, Jan Bělohlávek⁷, Jan Hovdenes⁸, Paolo Pelosi^{9

10}, David Erlinge³, Claudia Schrag¹¹, Ondrej Smid⁷, Iole Brunetti^{9

10}, Christian Rylander¹², Paul J Young¹³, Manoj Saxena¹⁴, Anders Åneman¹⁵, Alain Cariou¹⁶, Clifton Callaway¹⁷, Glenn M Eastwood¹⁸, Matthias Haenggi¹⁹, Michael Joannidis²⁰, Thomas R Keeble^{21

22}, Hans Kirkegaard²³, Christoph Leithner²⁴, Helena Levin²⁵, Alistair D Nichol^{26

27}, Matt P G Morgan⁶, Per Nordberg²⁸, Mauro Oddo²⁹, Christian Storm³⁰, Fabio Silvio Taccone³¹, Matthew Thomas³², John Bro-Jeppesen², Janneke Horn³³, Jesper Kjaergaard², Michael Kuiper³⁴, Tommaso Pellis³⁵, Pascal Stammet^{36

37}, Michael Jaeger Wanscher², Hans Friberg³⁸, Niklas Nielsen¹, Janus Christian Jakobsen^{39

40}

Affiliations

¹ Anesthesiology and Intensive Care, Department of Clinical Sciences, Helsingborg Hospital Lund, Lund University, Lund, Sweden.
² Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen.
³ Cardiology, Department of Clinical Sciences, Skåne University Hospital Lund, Lund University, Lund, Sweden.
⁴ Neurology, Department of Clinical Sciences, Skåne University Hospital Lund, Lund University, Lund, Sweden.
⁵ Clinical Studies Sweden-Forum South, Skåne University Hospital, Lund, Sweden.
⁶ Adult Critical Care, University Hospital of Wales, Cardiff, United Kingdom.
⁷ Cardiovascular Medicine, Second Department of Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic.
⁸ Division of Emergencies and Critical Care, Department of Anesthesiology, Oslo University Hospital, Rikshospitalet, Oslo.
⁹ Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
¹⁰ Anesthesiology and Critical Care, San Martino Policlinico Hospital, Scientific Institute for Research, Hospitalization and Healthcare for Oncology and Neurosciences, University of Genoa, Genoa, Italy.
¹¹ Intensive Care Department, Kantonspital St. Gallen, St. Gallen, Switzerland.
¹² Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹³ Intensive Care Unit, Medical Research Institute of New Zealand, Wellington Hospital, Wellington, New Zealand.
¹⁴ Division of Critical Care and Trauma, George Institute for Global Health, Sydney.
¹⁵ Department of Intensive Care, Liverpool Hospital, Sydney.
¹⁶ Cochin University Hospital, Descartes University of Paris, Paris.
¹⁷ Department of Emergency Medicine, University of Pittsburgh, Pittsburgh.
¹⁸ Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
¹⁹ Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
²⁰ Division of Intensive and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
²¹ Essex Cardiothoracic Centre, Basildon, United Kingdom.
²² Anglia Ruskin School of Medicine, Chelmsford, Essex, United Kingdom.
²³ Department of Clinical Medicine, Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
²⁴ Klinik und Hochschulambulanz für Neurologie, Charité-Universitätzmedizin, Berlin.
²⁵ Anesthesiology and Intensive Care, Department of Clinical Sciences, Skåne University Hospital Lund, Lund University, Lund, Sweden.
²⁶ University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin.
²⁷ School of Public Health and Preventive Medicine, Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
²⁸ Department of Clinical Science and Education, Center for Resuscitation Science, Karolinska Institutet, Södersjukhuset, Stockholm.
²⁹ Adult Intensive Care Medicine Service, Neuroscience Critical Care Research Group, Vaud University Hospital Center, University of Lausanne, Lausanne, Switzerland.
³⁰ Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin.
³¹ Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels.
³² Department of Intensive Care, Bristol Royal Infirmary, Bristol, United Kingdom.
³³ Department of Intensive Care, Academic Medical Center, Amsterdam.
³⁴ Department of Intensive Care, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
³⁵ Intensive Care Unit, Santa Maria degli Angeli, Pordenone, Italy.
³⁶ Department of Intensive Care Medicine, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
³⁷ Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
³⁸ Anesthesia and Intensive Care, Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Lund, Sweden.
³⁹ Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen.
⁴⁰ Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

PMID: 38319850
DOI: 10.1056/EVIDoa2200137

Abstract

Hypothermia versus Normothermia after Cardiac ArrestHolgersson et al. perform an individual patient data meta-analysis of the TTM and TTM2 trials of hypothermia after cardiac arrest and find no difference in 6-month mortality with hypothermia to 33°C versus normothermia.

Publication types

Meta-Analysis

MeSH terms

Body Temperature
Heart Arrest* / therapy
Humans
Hypothermia*
Hypothermia, Induced*
Temperature