Discontinuation of Infliximab Therapy in Patients with Crohn's Disease

Sine Buhl; Casper Steenholdt; Jørn Brynskov; Katrine Risager Christensen; Maria Dorn-Rasmussen; Ole Østergaard Thomsen; Klaus Bendtzen; Tobias Wirenfeldt Klausen; Jens Frederik Dahlerup; Niels Thorsgaard; Jørgen Jahnsen; Akbar Molazahi; Natalia Pedersen; Jens Kjeldsen; Sven Almer; Eva Efsen Dahl; Ida Vind; Annett Gerhardt Cannon; Jan Marsal; Taina Sipponen; Jørgen Steen Agnholt; Hendrika Adriana Linda Kievit; Synnøve Louise Aure; Lars Martinsen; Svetlana Meisner; Jane Møller Hansen; Mark Andrew Ainsworth

doi:10.1056/EVIDoa2200061

Discontinuation of Infliximab Therapy in Patients with Crohn's Disease

NEJM Evid. 2022 Aug;1(8):EVIDoa2200061. doi: 10.1056/EVIDoa2200061. Epub 2022 Jun 14.

Authors

Sine Buhl¹, Casper Steenholdt¹, Jørn Brynskov¹, Katrine Risager Christensen¹, Maria Dorn-Rasmussen¹, Ole Østergaard Thomsen¹, Klaus Bendtzen², Tobias Wirenfeldt Klausen¹, Jens Frederik Dahlerup³, Niels Thorsgaard⁴, Jørgen Jahnsen⁵, Akbar Molazahi⁶, Natalia Pedersen⁷, Jens Kjeldsen⁸, Sven Almer^{9

10}, Eva Efsen Dahl¹¹, Ida Vind¹², Annett Gerhardt Cannon¹³, Jan Marsal¹⁴, Taina Sipponen¹⁵, Jørgen Steen Agnholt³, Hendrika Adriana Linda Kievit⁴, Synnøve Louise Aure⁵, Lars Martinsen⁶, Svetlana Meisner⁷, Jane Møller Hansen⁸, Mark Andrew Ainsworth^{1

8}

Affiliations

¹ Department of Gastroenterology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
² Institute for Inflammation Research IRR, Rigshospitalet University Hospital, Copenhagen.
³ Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
⁴ Department of Medical Diseases, Herning Regional Hospital, Herning, Denmark.
⁵ Department of Gastroenterology, Akershus University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo.
⁶ Department of Medical Diseases, Nykøbing F. Regional Hospital, Nykøbing, Denmark.
⁷ Department of Gastroenterology, Slagelse Regional Hospital, Slagelse, Denmark.
⁸ Department of Medical Gastroenterology S, Odense University Hospital, Odense, Denmark.
⁹ Inflammatory Bowel Disease Unit, Division of Gastroenterology, Karolinska University Hospital, Stockholm, Sweden.
¹⁰ Departement of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
¹¹ Department of Gastroenterology K, Copenhagen University Hospital-Bispebjerg, Frederiksberg, Denmark.
¹² Department of Gastroenterology, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.
¹³ Diagnostic Center, Silkeborg Regional Hospital, Central Jutland, Denmark.
¹⁴ Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden.
¹⁵ Gastroenterology, Abdominal Center, Helsinki University Hospital, University of Helsinki, Helsinki.

PMID: 38319804
DOI: 10.1056/EVIDoa2200061

Abstract

Infliximab Discontinuation in Patients with Crohn's DiseaseThis randomized controlled trial explores infliximab withdrawal in patients with Crohn's disease in clinical, biochemical, and endoscopic remission with long-term infliximab maintenance therapy. Time to relapse was significantly shorter among patients who discontinued infliximab than among those who continued therapy.