Efficacy and safety of vibrating capsule in treatment of chronic idiopathic constipation: a systematic review and meta-analysis of randomized controlled trials

Hossein Haghbin; Nurruddinkhodja Zakirkhodjaev; Manesh Kumar Gangwani; Azizullah Beran; Wade Lee-Smith; Michael H Piper; Muhammad Aziz

doi:10.21037/tgh-23-64

Efficacy and safety of vibrating capsule in treatment of chronic idiopathic constipation: a systematic review and meta-analysis of randomized controlled trials

Transl Gastroenterol Hepatol. 2024 Jan 16:9:8. doi: 10.21037/tgh-23-64. eCollection 2024.

Authors

Hossein Haghbin¹, Nurruddinkhodja Zakirkhodjaev², Manesh Kumar Gangwani³, Azizullah Beran⁴, Wade Lee-Smith⁵, Michael H Piper¹, Muhammad Aziz⁶

Affiliations

¹ Division of Gastroenterology, Ascension Providence Hospital, Southfield, MI, USA.
² Division of Occupational and Environmental Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
³ Department of Internal Medicine, University of Toledo, Toledo, OH, USA.
⁴ Indiana University School of Medicine, Indianapolis, IN, USA.
⁵ University of Toledo Libraries, University of Toledo, Toledo, OH, USA.
⁶ Division of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.

Abstract

Background: Multiple pharmacological interventions and modalities are available for managing chronic idiopathic constipation (CIC), with variable efficacy. Vibrating capsule (VC) is a device that has shown variable results in alleviating constipation by tactile stimulation of the colonic wall and inducing peristalsis. This meta-analysis is to investigate the efficacy and safety of this modality.

Methods: Comprehensive literature search was performed through June 14th, 2023, on databases including Embase, PubMed/MEDLINE, Cochrane Central, Web of Science, Global Index Medicus, and Google Scholar. Core concepts of VC, constipation, and bowel movement were searched. The DerSimonian-Laird method and random effects model were utilized. We calculated odds ratio (OR) and mean difference (MD) for proportional and continuous variables, respectively, with 95% confidence interval (CI) and a P value of <0.05 considered statistically significant.

Results: The search strategy yielded 117 articles. Four studies with 705 total patients were finalized comparing VC to placebo/sham treatment. The pooled complete spontaneous bowel movement (CSBM), defined as bowel movement without use of laxatives within the last 48 hours with sense of complete evacuation did not achieve statistical improvement with VC (MD =0.153; 95% CI: -0.218 to 0.523; P=0.422). However, spontaneous bowel movement (SBM), defined as bowel movement without use of laxatives within the last 48 hours, showed statistical improvement with VC (MD =0.159; 95% CI: 0.095 to 0.223; P<0.001). VC didn't show an increase in pooled adverse events (OR =1.431; 95% CI: 0.702 to 2.916; P=0.324).

Conclusions: The systematic review and meta-analysis suggest that VC is safe and efficacious in some outcomes, however, larger randomized controlled trials (RCTs) and real-world data are needed to establish this.

Keywords: Chronic idiopathic constipation (CIC); colon; meta-analysis; spontaneous bowel movement (SBM); vibrating capsule (VC).