Correlation between systemic inflammatory response index and thyroid function: 2009-2012 NHANES results

Front Endocrinol (Lausanne). 2024 Jan 22:14:1305386. doi: 10.3389/fendo.2023.1305386. eCollection 2023.

Abstract

Aims: This study investigates the relationship between the Systemic Inflammatory Response Index (SIRI) and thyroid function.

Methods: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2009-2012, we excluded participants lacking SIRI or thyroid function data, those under 20 years, and pregnant individuals. SIRI was determined using blood samples. We conducted weighted multivariate regression and subgroup analyses to discern the independent relationship between SIRI and thyroid function.

Results: The study included 1,641 subjects, with an average age of 47.26±16.77 years, including 48.65% males and 51.35% females. The population was divided into three SIRI-based groups (Q1-Q3). Q3, compared to Q1, exhibited higher age-at-onset, greater male prevalence, and increased levels of FT3, FT4, TT4, leukocytes, and triglycerides. This group also showed a higher incidence of diabetes, hypertension, and smoking. Notably, Q1 had lower LDL and HDL levels. SIRI maintained a positive association with FT4 (β = 0.01, 95% CI = 0.00-0.03, P for trend = 0.0071), TT4 (β = 0.20, 95% CI = 0.10, 0.31, P for trend=0.0001), and TPOAb (β = 8.0, 95% CI = 1.77-14.30, P for trend = 0.0120), indicating that each quartile increase in SIRI corresponded to a 0.01 ng/dL increase in FT4, a 0.2 g/dL increase in TT4, and an 8.03 IU/mL rise in TPOAb. The subgroup analysis suggested the SIRI-thyroid function correlation was influenced by hypertension.

Conclusion: Inflammation may impact the development and progression of thyroid function disorders. Proactive anti-inflammatory treatment might mitigate thyroid abnormalities.

Keywords: national health and nutrition examination survey; positive correlation; systemic inflammatory response index; thyroid function; thyroid hormone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Hypertension*
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Pregnancy
  • Systemic Inflammatory Response Syndrome
  • Thyroid Diseases* / epidemiology
  • Thyroid Hormones

Substances

  • Thyroid Hormones

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by Qilu Chinese Medicine Advantage Specialist cluster Project (project number: YWC2022ZKJQ0003), Explored the mechanism of promoting mesenteric vascular repair in the treatment of Crohn’s enteritis by adding flavor to Si-Miao Yong’an Tang based on TGF-β1/Smads signaling pathway(project number: M-2023305) and Shandong University of Traditional Chinese Medicine Hospital "Young Famous Traditional Chinese Medicine Practitioners" Cultivation Program in 2023.