Evaluation of on- and off-target effects of self-assembled epidermal growth factor receptor small interfering RNA delivery system

Hongyuan Guo; Yuanyuan Su; Ruoyan Zhang; Xiao Hu; Hao Zhu; Xin Yan; Chen-Yu Zhang; Xu Guo; Zhen Zhou; Xi Chen

doi:10.1002/ctm2.1579

Evaluation of on- and off-target effects of self-assembled epidermal growth factor receptor small interfering RNA delivery system

Clin Transl Med. 2024 Feb;14(2):e1579. doi: 10.1002/ctm2.1579.

Authors

Hongyuan Guo^{1

2

3

4}, Yuanyuan Su¹, Ruoyan Zhang¹, Xiao Hu¹, Hao Zhu⁵, Xin Yan⁶, Chen-Yu Zhang^{1

3

4}, Xu Guo⁷, Zhen Zhou^{1

2

3}, Xi Chen^{1

2

4}

Affiliations

¹ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China.
² Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, China.
³ Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing, China.
⁴ Institute of Artificial Intelligence Biomedicine, Nanjing University, Nanjing, China.
⁵ Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁶ Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
⁷ Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ErbB Receptors* / genetics
ErbB Receptors* / metabolism
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism

Substances

RNA, Small Interfering
ErbB Receptors

Publication types

MeSH terms

Substances

Grants and funding