Microenvironment-differential Imaging of Demethylated Metabolites of Methionine for Identifying Ferroptosis Regional Preferences with Path-independent Equifinal Fluorescence Probes

Angew Chem Int Ed Engl. 2024 Apr 8;63(15):e202400459. doi: 10.1002/anie.202400459. Epub 2024 Feb 23.

Authors

Yuanchao Zhang¹, Xinrui Ji², Ping Han³, Yuxia Liu¹, Pu Chen², Guang Chen¹

Affiliations

¹ College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology, Xi'an, 710021, China.
² Department of Chemical Engineering and Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2 L3G1, Canada.
³ College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, China.

PMID: 38317310
DOI: 10.1002/anie.202400459

Abstract

We realized the microenvironment-differential Imaging of demethylated metabolites of methionine and the regional regulation of ferroptosis.

Keywords: Demethylated metabolites; Differential imaging; Methionine; Preference of ferroptosis.

© 2024 Wiley‐VCH GmbH.

MeSH terms

Diagnostic Imaging
Ferroptosis*
Fluorescence
Methionine*
Racemethionine
Tumor Microenvironment

Substances

Methionine
Racemethionine

Grants and funding