Diabetic Retinopathy - Pathophysiology to Treatment: A Review

Randhir Dahiya; Aditya Walia; Jasleen Kaur; Praveen Kumar; Inderjeet Verma; Nidhi Rani

doi:10.2174/0115733998259940231105200251

Diabetic Retinopathy - Pathophysiology to Treatment: A Review

Curr Diabetes Rev. 2024 Jan 22. doi: 10.2174/0115733998259940231105200251. Online ahead of print.

Authors

Randhir Dahiya^{1

2}, Aditya Walia³, Jasleen Kaur³, Praveen Kumar⁴, Inderjeet Verma⁵, Nidhi Rani³

Affiliations

¹ Department of Pharmacology, Central University of Punjab, Bathinda, Punjab, India.
² Department of Pharmacy, Graphic Era Hill University, Dehradun, India.
³ Chitkara College of Pharmacy, Chitkara University, Punjab, India.
⁴ SunPharma, Hill Top Area, Vill. Bhatolikalan, P.O. Barotiwala, Distt.Solan, Himachal Pradesh, 174103, India.
⁵ MM College of Pharmacy, Maharishi Markandeshwar (deemed to be) University, Mullana, Ambala, Haryana, India.

PMID: 38315658
DOI: 10.2174/0115733998259940231105200251

Abstract

Diabetic retinopathy (DR) is a microvascular disease affecting the eyes of diabetic patients, and is the most prevalent complication of diabetes mellitus. Vision improvement is not possible in the majority of DR patients. Several studies have indicated that microvascular changes, inflammation, oxidative stress, and retinal neurodegeneration are involved in the pathogenesis of DR. Therefore, there is an urgent need for the development of new and effective treatment for DR. Understanding the molecular mechanisms involved in the pathogenesis of disease will pave a way for better treatment and management of DR. This article has emphasized the molecular pathogenesis and treatment of DR.

Keywords: Diabetic Retinopathy; Pre-proliferative diabetic retinopathy; Proliferative diabetic retinopathy; Retinopathy.