The Applications of CircRNA in the Diagnosis and Treatment of Alzheimer's Disease

Xueyi Wen; Cheng Huang; Hesong Xie; Di Hu; Juyu Luo; Keshen Li

doi:10.1007/s12035-024-03977-0

The Applications of CircRNA in the Diagnosis and Treatment of Alzheimer's Disease

Mol Neurobiol. 2024 Feb 5. doi: 10.1007/s12035-024-03977-0. Online ahead of print.

Authors

Xueyi Wen^{1

2}, Cheng Huang^{1

2}, Hesong Xie^{1

2}, Di Hu^{1

2}, Juyu Luo^{1

2}, Keshen Li^{3

4}

Affiliations

¹ Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.
² Clinical Neuroscience Institute, Jinan University, Guangzhou, 510632, China.
³ Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China. likeshen1971@126.com.
⁴ Clinical Neuroscience Institute, Jinan University, Guangzhou, 510632, China. likeshen1971@126.com.

PMID: 38315302
DOI: 10.1007/s12035-024-03977-0

Abstract

Early diagnosis and intervention are key to the treatment of Alzheimer's disease (AD). There is an urgent need for new biomarkers and molecular targets for the detection and treatment of early Alzheimer's pathology. Circular RNA (circRNA) is a newly discovered non-coding RNA with a special type of covalently closed single strand, with potential preventive and therapeutic applications in a variety of diseases. New studies in the field of circRNA in AD have made many exciting new discoveries in recent years, some of which have not received sufficient attention but have important research implications. This review will focus on existing studies of circRNA in AD and discuss future translational perspectives of proposed circRNA strategies for clinical application in AD.

Keywords: Alzheimer’s disease; Biomarkers; CircRNA; Diagnosis; Treatment.

Publication types

Review