Comparison of Safety and Efficacy of Two Brands of Botulinum Toxin A for the Treatment of Lateral Canthal Lines (Crow's Feet): A Split-Face Study

Chaithra Shenoy; Ritu Agrawal; Byalakere Shivanna Chandrashekar; Rajesh Lalchandani

doi:10.4103/JCAS.JCAS_133_23

Comparison of Safety and Efficacy of Two Brands of Botulinum Toxin A for the Treatment of Lateral Canthal Lines (Crow's Feet): A Split-Face Study

J Cutan Aesthet Surg. 2023 Oct-Dec;16(4):270-278. doi: 10.4103/JCAS.JCAS_133_23.

Authors

Chaithra Shenoy¹, Ritu Agrawal¹, Byalakere Shivanna Chandrashekar¹, Rajesh Lalchandani²

Affiliations

¹ Department of Dermatology, CUTIS Academy of Cutaneous Science, Bengaluru, Karnataka, India.
² Gufic Biosciences Limited, Mumbai, India.

Abstract

Aim: To compare the safety and efficacy of Stunnox with the international brand of botulinum toxin A on lateral canthal lines.

Materials and methods: This was a nonrandomized, controlled, pilot, split-face study in 47 patients who were given two brands of Botulinum toxin A for the treatment of lateral canthal lines for 12 weeks. Evaluation of lines was assessed with grades of 0 (none), 1 (mild), 2 (moderate), and 3 (severe) at a maximum smile and rest by using ANTERA 3D camera.

Results: There was a statistical significance in lateral canthal lines wrinkles reduction on the Stunnox sides compared to pretreatment and at weeks 4, 8, and 12, respectively (all P < 0.05). The wrinkle reduction was similar to the effects of the control internationally available brand of botulinum toxin A. The clinical improvement of lateral canthal line wrinkles was greatest at 4 weeks after injection and the improvement lasted until 12 weeks of treatment with no adverse events observed.

Conclusion: In this split-face study, Stunnox botulinum toxin A showed a moderate but significant wrinkle-soothing effect without obvious side effects on the lateral canthal.

Keywords: ANTERA 3D; Stunnox; botulinum toxin A; lateral canthal lines; spit face; wrinkles.