Mast cell in infantile hemangioma

Meng Xia; Wenying Liu; Fang Hou

doi:10.3389/fonc.2024.1304478

Mast cell in infantile hemangioma

Front Oncol. 2024 Jan 19:14:1304478. doi: 10.3389/fonc.2024.1304478. eCollection 2024.

Authors

Meng Xia¹, Wenying Liu¹, Fang Hou¹

Affiliation

¹ Department of Pediatric Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Abstract

Infantile hemangioma (IH) is the most common benign vascular tumor characterized by three phases - proliferation, early involution and late involution. Mast cells (MCs) play an important role in allergic reactions and numerous diseases, including tumors. While the mechanisms underlying MCs migration, activation and function in the life cycle of IH remain unclear, previous studies suggested that MCs circulate through the vasculature and migrate into IH, and subsequently mature and get activated. Estradiol (E2) emerges as a potential attractant for MC migration into IH and their subsequent activation. In various stages of IH, activated MCs secrete both proangiogenic and anti-angiogenic modulators, absorbed by various cells adjacent to them. Imbalances in these modulators may contribute to IH proliferation and involution.

Keywords: anti-angiogenesis; estradiol; infantile hemangioma; mast cell; proangiogenesis.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (Grant No. 81300238), Key research Project of Sichuan Provincial Science and Technology Department (Grant No. 2021YFS0381) and Specialized Research Foundation of Sichuan Provincial People’s Hospital (Grant No.2021ZX03).