Hypersensitivity reactions following vein closure therapy with venasealTM (n-butyl- 2-cyanoacrylate)

Abby Lanakiev; Christopher D Codispodi; Payal D Patel

doi:10.1177/17085381221125841

Hypersensitivity reactions following vein closure therapy with venaseal^TM (n-butyl- 2-cyanoacrylate)

Vascular. 2024 Feb;32(1):179-181. doi: 10.1177/17085381221125841. Epub 2022 Sep 13.

Authors

Abby Lanakiev¹, Christopher D Codispodi², Payal D Patel²

Affiliations

¹ Rush University Medical College, Chicago, IL, USA.
² Division of Allergy and Immunology, Rush University Medical College, Chicago, IL, USARush University Medical Center, Chicago, IL, USA.

PMID: 38308425
DOI: 10.1177/17085381221125841

Abstract

VenaSeal^TM is composed of a cyanoacrylate adhesive compound often utilized for chronic venous stasis treatment. Rare case reports of hypersensitivity reactions to this compound exist. We present the first case of dermatographism and angioedema after utilization of VenaSeal^TM successfully treated via high dose antihistamines. We also present a case of type IV hypersensitivity to VenaSeal^TM, a cyanoacrylate, occurring in a patient with known meth(acrylate) allergy indicating a possible cross reactivity between these acrylate groups.

Keywords: VenaSealTM; acrylate; hypersensitivity; rash; varicose vein.

Publication types

Case Reports

MeSH terms

Cyanoacrylates / adverse effects
Enbucrilate* / adverse effects
Humans
Hypersensitivity*
Saphenous Vein
Treatment Outcome
Varicose Veins* / therapy
Venous Insufficiency* / diagnostic imaging
Venous Insufficiency* / therapy

Substances

Enbucrilate
Cyanoacrylates