Invasive mucinous adenocarcinoma of the lung with bronchorrhea - A marked reduction volume of sputum after SARS-CoV-2 infection

Xin Liu; Xinyue Zhou; Xiaocong Zhang; Lingling Sun; Guangdan Zhao; Shitao Mao; Fangzhi Li; Xiu Gu; Paul J Wolters; Shuo Liu

doi:10.1016/j.rmcr.2024.101982

Invasive mucinous adenocarcinoma of the lung with bronchorrhea - A marked reduction volume of sputum after SARS-CoV-2 infection

Respir Med Case Rep. 2024 Jan 12:47:101982. doi: 10.1016/j.rmcr.2024.101982. eCollection 2024.

Authors

Affiliations

¹ Department of Respiratory Medicine, The Fourth Hospital of China Medical University, Shenyang, Liaoning, 110032, PR China.
² Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, CA, USA.

Abstract

Bronchorrhea is a watery sputum volume of at least 100 mL/day, which is commonly associated with lung malignancies. We report a 57-year-old woman was admitted to the hospital with a cough, profuse sputum. Chest CTs showed crazy paving pattern and lung nodules. Cell nests were visible on the Thinprep Cytologic Test. The case was considered an invasive mucinous adenocarcinoma of the lung combined with bronchorrhea. Significantly, the sputum volume declined rapidly and did not rise again when the patient was diagnosed with COVID-19 and treated with nirmatrelvir/ritonavir. This case is suggestive of studies related to regulatory mediators associated with bronchorrhea.

Keywords: Bronchorrhea; COVID-19; Invasive mucinous adenocarcinoma.

Publication types

Case Reports