We report a human coronavirus OC43 infection outbreak in hospitalized patients and healthcare workers in São Paulo, Brazil, occurring after SARS-CoV-2 cases disappeared. Infection was associated with healthcare workers in 5 (29.4%) patients. Routine surveillance including a respiratory virus panel can improve coronavirus detection in both healthcare professionals and patients.
Keywords: Brazil; COVID-19; SARS; SARS-CoV-2; São Paulo; betacoronavirus; coronavirus; coronavirus disease; human coronavirus; outbreak; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.