For the first time, the two factors (the number of sites in the transition state and the nature of the catalytically active species) that affect the energy barriers (Ea and ΔG‡) in atmospheric aldehyde reactions are proposed. The contribution of each factor to the energy barriers of the ammonization and amination stages, dehydration, and intramolecular hydrogen transfer is studied using the example of the acetaldehyde and glyoxal interactions with ammonia in aqueous solution. A regular decrease in energy barriers is observed in a series of 4-, 6-, and 8-membered transition states (TSs) regardless of the nature of the catalytically active species and their numbers. The 8-membered TSs of ammonization, amination, and dehydration reactions are the most efficient catalytic systems. The role of the nature of catalytically active species is secondary and is expressed in different cases through the influence of entropy and different acidity/basicity of catalytically active species and their structures. The regularities for the stage of intramolecular hydrogen transfer stand out from those for the ammonization, amination, and dehydration stages. The intramolecular hydrogen transfer is organized by three atoms in TSs without the participation of catalytically active species, while the 5- and 7-membered TSs are formed with the participation of such species. A proportional decrease in energy barrier with a sequential increase in the number of TS sites (3-, 5-, and 7-) is not observed. A sharp decrease in the barriers occurs only during the formation of the 7-membered TSs, while the 5-membered structures lie above the 3-membered catalytically inactive structures on the potential energy surface (PES) regardless of the nature of the species forming these structures.